A first-in-human phase I study to evaluate the MEK1/2 inhibitor, cobimetinib, administered daily in patients with advanced solid tumors-Reference-Cited by-同舟云学术

A first-in-human phase I study to evaluate the MEK1/2 inhibitor, cobimetinib, administered daily in patients with advanced solid tumors

Published:2016-07-16 Issue:5 Volume:34 Page:604-613
ISSN:0167-6997
Container-title:Investigational New Drugs
language:en
Short-container-title:Invest New Drugs

Author:

Rosen Lee S.,LoRusso Patricia,Ma Wen Wee,Goldman Jonathan W.,Weise Amy,Colevas A. Dimitrios,Adjei Alex,Yazji Salim,Shen Angela,Johnston Stuart,Hsieh Hsin-Ju,Chan Iris T.,Sikic Branimir I.

Funder

Genentech (US)

Genentech

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Link

http://link.springer.com/content/pdf/10.1007/s10637-016-0374-3.pdf

Reference36 articles.

1. Davies H, Bignell GR, Cox C, et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417:949–954. doi: 10.1111/ced.12015

2. Allen LF, Sebolt-Leopold J, Meyer MB (2003) CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol 30(5 Suppl 16):105–116

3. Malumbres M, Barbacid M (2003) RAS oncogenes: the first 30 years. Nat Rev Cancer 3:459–65. Erratum in: Nat Rev Cancer 3:708

4. Bamford S, Dawson E, Forbes S, et al. (2004) The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer 91:355–358

5. Karnoub A, Weinberg RA (2008) Ras oncogenes: split personalities. Nat Rev Mol Cell Biol 9:517–531. doi: 10.1038/nrm2438

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