A phase II study of tipifarnib and gemcitabine in metastatic breast cancer

Author:

Yam Clinton,Murthy Rashmi K.,Valero Vicente,Szklaruk Janio,Shroff Girish S.,Stalzer Carol J.,Buzdar Aman U.,Murray James L.,Yang Wei,Hortobagyi Gabriel N.,Moulder Stacy L.,Arun Banu

Funder

National Cancer Institute

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference35 articles.

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3. Kelland LR, Smith V, Valenti M, Patterson L, Clarke PA, Detre S, End D, Howes AJ, Dowsett M, Workman P, Johnston SR (2001) Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer. Clin Cancer Res 7(11):3544–3550

4. Izbicka E, Campos D, Carrizales G, Patnaik A (2005) Biomarkers of anticancer activity of R115777 (Tipifarnib, Zarnestra) in human breast cancer models in vitro. Anticancer Res 25(5):3215–3223

5. Warnberg F, White D, Anderson E, Knox F, Clarke RB, Morris J, Bundred NJ (2006) Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo. Breast Cancer Res 8(2):R21. https://doi.org/10.1186/bcr1395

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