Bortezomib overcomes MGMT-related resistance of glioblastoma cell lines to temozolomide in a schedule-dependent manner

Author:

Vlachostergios Panagiotis J.,Hatzidaki Eleana,Befani Christina D.,Liakos Panagiotis,Papandreou Christos N.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference56 articles.

1. Preusser M, de Ribaupierre S, Wöhrer A et al (2011) Current concepts and management of glioblastoma. Ann Neurol 70:9–21

2. Christmann M, Verbeek B, Roos WP, Kaina B (1816) O(6)-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry. Biochim Biophys Acta 2011:179–190

3. Xu-Welliver M, Pegg AE (2002) Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase. Carcinogenesis 23:823–830

4. Hegi ME, Liu L, Herman JG et al (2008) Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J Clin Oncol 26:4189–4199

5. Harris LC, Remack JS, Houghton PJ, Brent TP (1996) Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA methyltransferase gene. Cancer Res 56:2029–2032

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