A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers-Reference-Cited by-同舟云学术

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A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers

Published:2022-04-11 Issue:4 Volume:40 Page:747-755
ISSN:0167-6997
Container-title:Investigational New Drugs
language:en
Short-container-title:Invest New Drugs

Author:

Gan Hui K.^ORCID,Parakh Sagun,Lee F. T.,Tebbutt Niall C.,Ameratunga Malaka,Lee Sze Ting,O’Keefe Graeme J.,Gong Sylvia J.,Vanrenen Christine,Caine Jaren,Giovannetti Mara,Murone Carmel,Scott Fiona E.,Guo Nancy,Burvenich Ingrid J. G.,Paine Cameron,Macri Mary J.,Kotsuma Masakatsu,Senaldi Giorgio,Venhaus Ralph,Scott Andrew M.

Funder

Daiichi-Sankyo

National Health and Medical Research Council

La Trobe University

Ludwig Institute for Cancer Research

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Link

https://link.springer.com/content/pdf/10.1007/s10637-022-01237-3.pdf

Reference23 articles.

1. Hasegawa J et al (2016) Novel anti-EphA2 antibody, DS-8895a for cancer treatment. Cancer Biol Ther 17(11):1158–1167

2. Burvenich IJ et al (2016) Molecular imaging and quantitation of EphA2 expression in Xenograft models with 89Zr-DS-8895a. J Nucl Med 57(6):974–980

3. Easty DJ, Herlyn M, Bennett DC (1995) Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis. Int J Cancer 60(1):129–136. https://doi.org/10.1002/ijc.2910600119

4. Nemoto T et al (1997) Overexpression of protein tyrosine kinases in human esophageal cancer. Pathobiology 65(4):195–203. https://doi.org/10.1159/000164123

5. Rosenberg IM et al (1997) Epithelial cell kinase-B61: an autocrine loop modulating intestinal epithelial migration and barrier function. Am J Physiol 273(4):G824–G832. https://doi.org/10.1152/ajpgi.1997.273.4.G824

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