Multilineage dysplasia is associated with a poorer prognosis in patients with de novo acute myeloid leukemia with intermediate-risk cytogenetics and wild-type NPM1

Author:

Rozman María, ,Navarro José-Tomás,Arenillas Leonor,Aventín Anna,Giménez Teresa,Alonso Esther,Perea Granada,Camós Mireia,Navarrete Mayda,Tuset Esperanza,Florensa Lourdes,Millá Fuensanta,Nomdedéu Josep,de la Banda Esmeralda,Díaz-Beyá Marina,Pratcorona Marta,Garrido Ana,Navarro Blanca,Brunet Salut,Sierra Jorge,Esteve Jordi

Publisher

Springer Science and Business Media LLC

Subject

Hematology,General Medicine

Reference14 articles.

1. Schlenk RF, Döhner K, Krauter J, Fröhling S, Corbacioglu A, Bullinger L, Habdank M, Späth D, Morgan M, Benner A, Schlegelberger B, Heil G, Ganser A, Döhner H (2008) Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 358:1909–1918

2. Vardiman JW, Brunning RD, Arber DA, Le Beau MM, Porwit A, Tefferi A, Bloomfield CD, Thiele J (2008) Introduction and overview of the classification of the myeloid neoplasms. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds) WHO classification of Tumors of Haematopoieticand Lymphoid Tissues. International Agency for Research on Cancer (IARC), Lyon, pp 18–30

3. Arber DA, Brunning RD, Orazi A, Bain BJ, Porwit A, Vardiman JW, Le Beau MM, Greenberg PL (2008) Acute myeloid leukemia with myelodysplasia-related changes. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds) WHO classification of tumors of haematopoietic and lymphoid tissues. International Agency for Research on Cancer (IARC), Lyon, pp 124–126

4. Wandt H, Schakel U, Kroschinsky F, Prange-Krex G, Mohr B, Thiede C, Pascheberg U, Soucek S, Schaich M, Ehninger G (2008) Multilineage dysplasia according to the World Health Organisation (WHO) classification in acute myeloid leukemia (AML) has no correlation with age and no independent prognostic relevance as analyzed in 1766 patients. Blood 111:1855–1861

5. Miesner M, Haferlach C, Bacher U, Weiss T, Macijewski K, Kohlmann A, Klein HU, Dugas M, Kern W, Schnittger S, Haferlach T (2010) Multilineage dysplasia (MLD) in acute myeloid leukemia (AML) correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: a comparison of 408 cases classified as “AML not otherwise specified” (AML-NOS) or “AML with myelodysplasia-related changes” (AML-MRC). Blood 116:2742–2751

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