Similar outcome after allogeneic stem cell transplantation with a modified FLAMSA conditioning protocol substituting 4 Gy TBI with treosulfan in an elderly population with high-risk AML

Author:

Holtick UdoORCID,Herling Marco,Pflug Natali,Chakupurakal Geothy,Leitzke Silke,Wolf Dominik,Hallek Michael,Scheid Christof,Chemnitz Jens M.

Publisher

Springer Science and Business Media LLC

Subject

Hematology,General Medicine

Reference25 articles.

1. Slavin S, Nagler A, Naparstek E, Kapelushnik Y, Aker M, Cividalli G et al (1998) Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 91:756–763

2. Champlin R, Khouri I, Shimoni A, Gajewski J, Kornblau S, Molldrem J et al (2000) Harnessing graft-versus-malignancy: non-myeloablative preparative regimens for allogeneic haematopoietic transplantation, an evolving strategy for adoptive immunotherapy. Br J Haematol 111:18–29

3. Gutierrez-Aguirre CH, Cantu-Rodriguez OG, Gonzalez-Llano O, Salazar-Riojas R, Martinez-Gonzalez O, Jaime-Perez JC et al (2007) Non-myeloablative hematopoietic stem cell transplantation is of limited value in advanced or refractory acute myeloblastic leukemia. Mex Experience Hematol 12:193–197

4. Magenau JM, Braun T, Reddy P, Parkin B, Pawarode A, Mineishi S, Choi S et al (2015) Allogeneic transplantation with myeloablative FluBu4 conditioning improves survival compared to reduced intensity FluBu2 conditioning for acute myeloid leukemia in remission. Ann Hematol 94(6):1033–1041

5. Schmid C, Schleuning M, Ledderose G, Tischer J, Kolb HJ (2005) Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome. J Clin Oncol 23:5675–5687

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