Single-agent brentuximab vedotin as frontline therapy for Hodgkin lymphoma patients with severe hepatic impairment: a report of two cases

Author:

Wang Yupeng,Wang Zi,Wei Chong,Zhao Danqing,Zhang Yan,Wang WeiORCID,Zhang Wei,Zhou Daobin

Funder

National High Level Hospital Clinical Research Funding

Publisher

Springer Science and Business Media LLC

Subject

Hematology,General Medicine

Reference5 articles.

1. Ortín X, Rodríguez-Luaces M, Bosch R, Lejeune M, Font L (2010) Acute liver failure as the first manifestation of very late relapsing of Hodgkin’s disease. Hematol Rep 2(1):e5. https://doi.org/10.4081/hr.2010.e5

2. Straus DJ, Długosz-Danecka M, Connors JM, Alekseev S, Illés Á, Picardi M, Lech-Maranda E, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Ramchandren R, Zinzani PL, Hutchings M, Munoz J, Lee HJ, Kim WS, Advani R et al (2021) Brentuximab vedotin with chemotherapy for stage III or IV classical Hodgkin lymphoma (ECHELON-1): 5-year update of an international, open-label, randomised, phase 3 trial. Lancet Haematol 8(6):e410–e421. https://doi.org/10.1016/s2352-3026(21)00102-2

3. Forero-Torres A, Holkova B, Goldschmidt J, Chen R, Olsen G, Boccia RV, Bordoni RE, Friedberg JW, Sharman JP, Palanca-Wessels MC, Wang Y, Yasenchak CA (2015) Phase 2 study of frontline brentuximab vedotin monotherapy in Hodgkin lymphoma patients aged 60 years and older. Blood 126(26):2798–2804. https://doi.org/10.1182/blood-2015-06-644336

4. Gupta A, Petrasek J, Sen S, Gopal P, Naina HV (2016) Single-agent brentuximab as bridging therapy for Hodgkin lymphoma patients with hepatic impairment. Clin Lymphoma Myeloma Leuk 16(2):e11–e14. https://doi.org/10.1016/j.clml.2015.11.015

5. Spathas N, Belia M, Giannikos T, Arapaki M, Efstathopoulou M, Tsourouflis G, Gainaru G, Asimakopoulos J, Tsaftaridis P, Angelopoulou MK, Plata E, Konstantopoulos K, Theodoros PV (2019) Successful reversal of severe liver function impairment with brentuximab vedotin in multiply relapsed/refractory classical Hodgkin lymphoma. J buon 24(6):2483–2489

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