Rare case of simultaneous occurrence of chronic neutrophil leukemia and T lymphoblastic lymphoma: case report and literature review

Author:

Wang Shi-xuan,Wang Fang,Tu Ye-chao,Zhou Yu-lan,Tu Song-tao,Wang Jie-yu,Lv Ke-bing,Li Fei

Abstract

AbstractChronic neutrophil leukemia (CNL) is a rare and life-threatening disease. Cases of CNL combined with lymphoma are rare. Here, we report a case of CNL with T-acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) in a 28-year-old male. After a regimen of ruxolitinib, VICLP (Vincristine, Idarubicin, Cyclophosphamide, Prednisone, Peg-asparaginase) regimen, high-dose cytarabine, and methotrexate regimens, the patient’s bone marrow condition partially resolved. However, when the disease relapsed four months later, despite attempts with selinexor, venetoclax, and CAG(aclarubicin hydrochloride, Algocytidine, Granulocyte Stimulating Factor) chemotherapy, the leukocytes and peripheral blood primitive cells reduced, but the bone marrow did not achieve remission. This pathogenesis may be related to microenvironmental immune escape under prolonged inflammatory stimulation and gene disruption affecting protein function due to colony-stimulating factor 3 receptor gene (CSF3R) mutations. For this type of disease, early intervention may delay disease progression.

Funder

the grants from the Science and Technology Innovation Base Construction Project of Jiangxi Province

the National Nature Science Foundation of China

Trainingthe Project of Major Leaders for Academic and Technical in Jiangxi Province

the key projects for scientific and technological cooperation of Jiangxi Province

Publisher

Springer Science and Business Media LLC

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