Association of cup-like nuclei in blasts with FLT3 and NPM1 mutations in acute myeloid leukemia

Author:

Park Borae G.,Chi Hyun-Sook,Jang Seongsoo,Park Chan-Jeoung,Kim Dae-Young,Lee Jung-Hee,Lee Je-Hwan,Lee Kyoo-Hyung

Publisher

Springer Science and Business Media LLC

Subject

Hematology,General Medicine

Reference27 articles.

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2. Orfao A, Chillon MC, Bortoluci AM, Lopez-Berges MC, Garcia-Sanz R, Gonzalez M, Tabernero MD, Garcia-Marcos MA, Rasillo AI, Hernandez-Rivas J, San Miguel JF (1999) The flow cytometric pattern of CD34, CD15 and CD13 expression in acute myeloblastic leukemia is highly characteristic of the presence of PML-RARalpha gene rearrangements. Haematologica 84(5):405–412

3. Scott AA, Head DR, Kopecky KJ, Appelbaum FR, Theil KS, Grever MR, Chen IM, Whittaker MH, Griffith BB, Licht JD et al (1994) HLA-DR−, CD33+, CD56+, CD16− myeloid/natural killer cell acute leukemia: a previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3. Blood 84(1):244–255

4. Kroschinsky FP, Schakel U, Fischer R, Mohr B, Oelschlaegel U, Repp R, Schaich M, Soucek S, Baretton G, Ehninger G, Thiede C (2008) Cup-like acute myeloid leukemia: new disease or artificial phenomenon? Haematologica 93(2):283–286. doi: 10.3324/haematol.11669

5. Chen W, Konoplev S, Medeiros LJ, Koeppen H, Leventaki V, Vadhan-Raj S, Jones D, Kantarjian HM, Falini B, Bueso-Ramos CE (2009) Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation. Cancer 115(23):5481–5489. doi: 10.1002/cncr.24610

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