Abstract
AbstractPreliminary clinical evidence suggests that metformin has TSH lowering effects in patients with T2DM and hypothyroidism or in those with TSH serum levels in the upper normal value. Also, metformin may exert a protective role against thyroid nodules growth in patients without insulin-resistance. The cross-talk between tyrosine kinase receptors and the G protein-coupled receptors (which the TSHR belongs to) has been already shown and IRS1 may represent the hub link between TSHR and IR pathways. By influencing IRS1 phosphorylation pattern, metformin may sensitize TSHR to TSH, thus explaining the findings of clinical studies. However, the existence of this molecular pathway must be confirmed through proper studies and further prospective randomized placebo-controlled studies are needed to confirm this hypothesis.
Funder
Università degli Studi di Catania
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Reference22 articles.
1. Altomare M, La Vignera S, Asero P, Recupero D, Condorelli RA, Scollo P, Gulisano A, Magro E, Tumino D, Tumino S, Vicari E, Leanza V, D’Agata R, Calogero AE (2013) High prevalence of thyroid dysfunction in pregnant women. J Endocrinol Invest 36(6):407–411
2. Chubb SA, Davis WA, Inman Z, Davis TM (2005) Prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes: the fremantle diabetes study. Clin Endocrinol (Oxf) 62:480–486
3. Cappelli C, Rotondi M, Pirola I, Agosti B, Gandossi E, Valentini U, De Martino E, Cimino A, Chiovato L, Agabiti-Rosei E, Castellano M (2009) TSH-lowering effect of metformin in type 2 diabetic patients: differences between euthyroid, untreated hypothyroid, and euthyroid on L-T4 therapy patients. Diabetes Care 32(9):1589–1590
4. Vigersky RA, Filmore-Nassar A, Glass AR (2006a) Thyrotropin suppression by metformin. J Clin Endocrinol Metab 91(1):225–227. https://doi.org/10.1210/jc.2005-1210
5. Isidro ML, Penín MA, Nemiña R, Cordido F (2007) Metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy. Endocrine 32(1):79–82
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