Changes in T-cell subpopulations in mice during prolonged experimental secondary infection with Echinococcus granulosus-Reference-Cited by-同舟云学术

Changes in T-cell subpopulations in mice during prolonged experimental secondary infection with Echinococcus granulosus

Published:1995-08-01 Issue:4 Volume:15 Page:201-208
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Rueda M. C.¹,Osuna A.²,De Rycke P. H.³,Janssen D.²

Affiliation:

1. Laboratorio de Análisis, Hospital Torrecardenas, Almería, Spain

2. Departamento de Parasitología, Universidad de Granada, Campus Universitario de Fuentenueva s/n, Granada E-18071, Spain

3. Laboratorium voor Zoöfysiologie, Universiteit Gent, K. L. Ledeganckstraat 35, B-9000 Gent, Belgium

Abstract

Balb/c mice were infected intraperitoneally with protoscoleces of Echinococcus granulosus. After 15 months of infection, and by means of flow cytometry, the expression of T-cell markers CD3, CD4, and CDS on T cells from peripheral blood, spleen, and thymus was analyzed and compared with that of age-matched controls. Infected mice had higher percentages of CD3+, and CD4+ cells in peripheral blood, and higher percentages of CD8+ cells in the spleen, when compared with control mice. CD4+ and CD8+ cells in peripheral blood and CD8+ cells in thymus also showed higher percentages of expression of interleukin-2 receptor. The results infer a role for interleukin-2 in experimental secondary echinococcosis.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/15/4/201/469069/bsr0150201.pdf

Reference23 articles.

1. Heath, D. D. (1982) in:The Biology of Echinococcus and Hydatid Disease. (Thompson, R. C. A., ed.) George Allen & Unwin, London, pp. 164–188.

2. Baron, R. W. and Tanner, C. E. (1977)Int. J. Parasitol. 7:489–495.

3. De Rycke, P. H. and Pennoit-De Cooman, E. (1973)Z. Parasitenkd. 42:49–59.

4. Yusuf, J. N., Frayha, G. J. and Malakian, A. H. (1975)Exp. Parasital. 38:30–37.

5. Araj, G. F., Matossian, R. M. and Frayha, G. J. (1977)Z. Parasitenkd. 52:23–30.

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