How We Treat Recurrent Glioblastoma Today and Current Evidence

Author:

Chaul-Barbosa Caroline,Marques Daniel Fernandes

Publisher

Springer Science and Business Media LLC

Subject

Oncology

Reference46 articles.

1. • Wick W, Gorlia T, Bendszus M, Taphoorn M, Sahm F, Harting I, et al. Lomustine and bevacizumab in progressive glioblastoma. N Engl J Med. 2017;377(20):1954–63. https://doi.org/10.1056/NEJMoa1707358 . The first published phase 3 trial with BEV in rGBM and did not show any gain in OS or in quality of life. However, FDA kept the appoval of BEV for rGBM.

2. •• Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H, et al. Glioma groups based on 1p/19q, IDH, and TERT promoter mutations in tumors. N Engl J Med. 2015;372(26):2499–508. https://doi.org/10.1056/NEJMoa1407279 . Published in New England Journal of Medicine , it was one of the most downloaded article in 2015. Some of these mutations were incorporated to WHO tumor classification.

3. Brzozowska A, Toruń A, Mazurkiewicz M. The impact of surgery on the efficacy of adjuvant therapy in glioblastoma multiforme. Adv Clin Exp Med. 2015;24(2):279–87. https://doi.org/10.17219/acem/40456 .

4. Sastry RA, Shankar GM, Gerstner ER, Curry WT. The impact of surgery on survival after progression of glioblastoma: a retrospective cohort analysis of a contemporary patient population. J Clin Neurosci. 2018;53:41–7. https://doi.org/10.1016/j.jocn.2018.04.004 .

5. • Ringel F, Pape H, Sabel M, Krex D, Bock HC, Misch M, et al. Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection. Neuro Oncol. 2016;18(1):96–104. https://doi.org/10.1093/neuonc/nov145 . Positive results regarding re-resection in rGBM, with a robust numer of patients.

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