Limb salvage in the skeletally immature patient

Author:

Lewis Valerae O.

Publisher

Springer Science and Business Media LLC

Subject

Oncology

Reference56 articles.

1. Benjamin R, Chawla S, Murray J, et al.: Preoperative chemotherapy for osteosarcoma: a treatment approach facilitating limb salvage with major prognostic indications. In Adjuvant Therapy of Cancer, vol 4. Edited by Jones S, Salmon S. Philadelphia: Grune and Stratton; 1984; 601–610.

2. Klein MJ, Kenan S, Lewis MM: Osteosarcoma: clinical and pathological considerations. Orthop Clin North Am 1989, 20:327–345.

3. Rosen G, Marcove RC, Huvos AG, et al.: Primary osteogenic sarcoma: eight-year experience with adjuvant chemotherapy. J Cancer Res Clin Oncol 1983, 106:55–67.

4. Simon MA, Aschliman MA, Thomas N, Mankin HJ: Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg Am 1986, 68:1331–1337. A retrospective multi-institutional study of 227 patients with osteosarcoma of the distal end of the femur was done to compare rates of local recurrence, metastasis, and survival. Three cohorts of patients who had had either a limb-sparing procedure, an above-the-knee amputation, or disarticulation of the hip were compared. The Kaplan-Meier estimates of the percentage of patients who survived and the percentage of patients without recurrent disease showed no difference among the three surgical groups (Mantel-Cox test statistic: P=0.8) after a median follow-up of 5 and a half years. Compared with above-theknee amputation or disarticulation of the hip, the use of a limb salvage procedure for osteosarcoma of the distal end of the femur did not shorten the disease-free interval or compromise long-term survival.

5. Whelan JS: Osteosarcoma. Eur J Cancer 1997, 33:1611–1618. A complete review of osteosarcoma including recent advances in molecular biology and chemotherapy.

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