Upfront Management of ALK-Rearranged Metastatic Non-small Cell Lung Cancer: One Inhibitor Fits All?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology
Link
http://link.springer.com/content/pdf/10.1007/s11912-020-00989-6.pdf
Reference70 articles.
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4. •• Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153):561–6 This paper described in 6.7% of NSCLC analyzed the presence of a chimeric protein generated by an intra-chromosomal inversion, which juxtapose EML4 and ALK and its transformative properties.
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