Hairy Cell Leukaemia
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology
Link
https://link.springer.com/content/pdf/10.1007/s11912-020-00911-0.pdf
Reference91 articles.
1. • Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. World heal organ Classif Tumours Haematop lymphoid tissue; 2017. https://doi.org/10.1017/CBO9781107415324.004. This revised classification contains updated diagnostic information on HCLc and HCLv. It also includes HCLv as a separate entity for the first time.
2. Dores GM, Matsuno RK, Weisenburger DD, Rosenberg PS, Anderson WF. Hairy cell leukaemia: a heterogeneous disease? Br J Haematol. 2008;142:45–51.
3. Hoffman MA. Clinical presentations and complications of hairy cell leukemia. Hematol Oncol Clin North Am. 2006;20:1065–73.
4. •• Tiacci E, Trifonov V, Schiavoni G, et al. BRAF mutations in hairy-cell leukemia. N Engl J Med. 2011;364:2305–15 The seminal paper describing the finding of the BRAF V600E mutation in an index case and subsequent validation as the causative mutation in HCLc, with the same mutation found in all of a further 47 sequenced HCLc cases. It describes the mechanism of action of the mutant BRAF protein, which produces constitutive activation of the RAF-MEK-ERK mitogen-activated protein kinase pathway in HCL causing uncontrolled proliferation. This paper defined the underlying genetic driver in HCLc and has led to the use of targeted BRAF inhibitor therapy.
5. Matutes E, Martínez-Trillos A, Campo E. Hairy cell leukaemia-variant: disease features and treatment. Best Pract Res Clin Haematol. 2015;28:253–63.
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