The Role of Surgery for Melanoma in an Era of Effective Systemic Therapy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology
Link
http://link.springer.com/content/pdf/10.1007/s11912-017-0575-8.pdf
Reference35 articles.
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3. Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363:711–23.
4. •• Morton DL, Thompson JF, Cochran AJ, et al. Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med. 2014;370:599–609. The Multicenter Selective Lymphadenectomy Trial (MSLT-I) is a phase 3 trial designed to determine whether identifying patients with clinically occult nodal melanoma metastases via sentinel node biopsy and then performing an immediate completion lymphadenectomy in those patients improves outcomes. Results of the study suggest that sentinel node biopsy and early completion lymphadenectomy do provide survival benefit to patients with intermediate thickness melanoma, most likely because those individuals in the biopsy group with clinically occult metastases at the time of the study were identified and treated, preventing regional recurrence. However, whether completion lymphadenectomy is necessary or whether removal of the sentinel nodes themselves provides adequate therapeutic benefit will be further addressed by MSLT-II (ongoing)
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