Advances in Molecular Profiling and Developing Clinical Trials of CNS Germ Cell Tumors: Present and Future Directions
Author:
Funder
Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Subject
Oncology
Link
https://link.springer.com/content/pdf/10.1007/s11912-022-01195-2.pdf
Reference52 articles.
1. •• Takami H, Fukuoka K, Fukushima S, Nakamura T, Mukasa A, Saito N, Yanagisawa T, Nakamura H, Sugiyama K, Kanamori M. Integrated clinical, histopathological, and molecular data analysis of 190 central nervous system germ cell tumors from the iGCT Consortium. Neuro Oncol. 2019;21:1565–77. The study included 190 CNS GCTs, and revealed germinoma prognosis depended on tumor location, marker-positive germinoma had worse prognosis, female GCTs had fewer MAPK pathway mutation, and basal ganglia GCTs had a higher percentage of PI3K pathway mutations.
2. Jennings MT, Gelman R, Hochberg F. Intracranial germ-cell tumors: natural history and pathogenesis. J Neurosurg. 1985;63:155–67. https://doi.org/10.3171/jns.1985.63.2.0155.
3. Takami H, Graffeo CS, Perry A, Giannini C, Daniels DJ. Epidemiology, natural history, and optimal management of neurohypophyseal germ cell tumors. J Neurosurg. 2020;1:1–9.
4. Takami H, Graffeo CS, Perry A, Giannini C, Daniels DJ. The third eye sees double: cohort study of clinical presentation, histology, surgical approaches, and ophthalmic outcomes in pineal region germ cell tumors. World Neurosurg. 2021;150:e482–90.
5. Gittleman H, Cioffi G, Vecchione-Koval T, Ostrom QT, Kruchko C, Osorio DS, Finlay JL, Barnholtz-Sloan JS. Descriptive epidemiology of germ cell tumors of the central nervous system diagnosed in the United States from 2006 to 2015. J Neurooncol. 2019;143:251–60.
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