Angiogenesis and melanoma

Author:

Dutcher Janice P.

Publisher

Springer Science and Business Media LLC

Subject

Oncology

Reference49 articles.

1. Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990, 82:4–6. Extensive preclinical work has demonstrated the importance of neo-angiogenesis to tumor growth and development.

2. Folkman J, Klagsbrun M: Angiogenic factors. Science 1987, 235:442–447.

3. Vlaykova T, Laurila P, Muhonen T, et al.: Prognostic value of tumour vascularity in metastatic melanoma and association of blood vessel density with vascular endothelial growth factor expression. Melanoma Res 1999, 9:59–68. Demonstration of the correlation of markers of neovascularization with biologic behavior has led to further research on inhibition of this mechanism.

4. Claffey KP, Brown LF, del Aguila LF, et al.: Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res 1996, 56:172–181. This study demonstrates the correlation of the expression of vascular growth factors with evidence of the progression of melanoma and demonstration of a paracrine mechanism.

5. Potgens AJ, van Altena MC, Lubsen NH, et al.: Analysis of the tumor vasculature and metastatic behavior of xenografts of human melanoma cell lines transfected with vascular permeability factor. Am J Pathol 1996, 148:1203–1217.

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