FTY720: Mechanisms of Action and Immunosuppressive Activity in Organ Transplantation

Author:

Suzuki Seiichi

Publisher

Springer Japan

Reference31 articles.

1. Fujita T, Yoneta M, Hirose, R, et al. (1995) Simple compounds, 2-alkyl-2-amino-1,3-propanediols, have potent immunosuppressive activity. Bioorg Med Chem Lett 5: 847–853

2. Baumann G (1992) Molecular mechanism of immunosuppressive agents. Transplant Proc 24:4–7

3. Chiba K, Yanagawa Y, Masubuchi Y, et al. (1998) FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol 160:5037–5044

4. Yanagawa Y, Sugahara K, Kataoka H, et al. (1998) FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. IL FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo. J Immunol 160:5493–5499

5. Li XK, Enosawa S, Kakefuda T, et al. (1997) FTY720, a novel immunosuppressive agent, enhances upregulation of the cell adhesion molecular ICAM-1 in TNF-alpha-treated human umbilical vein endothelial cells. Transplant Proc 29:1265–1266

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