Author:
Wu Wenhui,Li Xiurong,Di Jia,Zhou Hua,Niu Hongyan,Yang Min
Abstract
Abstract
Objectives
Multiple observational studies have shown that low serum level of 25-hydroxyvitamin D (25(OH)D) in patients with chronic kidney disease (CKD) have been associated with a faster progression of kidney disease and a higher risk of all-cause mortality. We aim to assess the association between dietary inflammatory index (DII) with Vitamin D in adults with CKD.
Method
The National Health and Nutrition Examination Survey appropriated participants from 2009 to 2018 were enrolled. The patients who were under the age of 18, pregnant, and having incomplete data were excluded. DII score were calculated based on a single 24-h dietary recall interview for each participant. Mutivariable regression analysis and subgroup analysis were utilized to determine the independent associations between vitamin D with DII in CKD patients.
Results
In total, 4283 individuals were finally included. The results showed a negative association between DII scores and 25(OH)D with statistical significance (β = – 1.83, 95% CI – 2.31, – 1.34, P < 0.001). In subgroup analysis stratified by gender, low eGFR, age and diabetes, the negative association between DII scores and 25(OH)D was still significant (all P for trend < 0.05). The results from interacion test indicated that the magnitude of the association was the same for the population with and without low eGFR (P for interacion = 0.464).
Conclusion
Higher consumption of pro-inflammatory diet correlates negatively with the 25(OH)D level in CKD patients with and without low eGFR. Anti-inflammatory diet management may reduce the reduction of vitamin D in CKD patients.
Funder
Jiangsu Provincial Medical Youth Talent
Changzhou Youth Talent Fund
the Science and Technology Bureau of Changzhou
Publisher
Springer Science and Business Media LLC
Cited by
4 articles.
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