Abstract
Abstract
Aim
Frailty is common and is reported to be associated with adverse outcomes in patients with chronic diseases in Western countries. However, the prevalence of frailty remains unclear in individuals with chronic kidney disease (CKD) in China. We examined the prevalence of frailty and factors associated with frailty in patients with CKD.
Methods
This was a cross-sectional analysis of 177 adult patients (mean age 54 ± 15 years, 52% men) with CKD from the open cohort entitled Physical Evaluation and Adverse outcomes for patients with chronic Kidney disease IN Guangdong (PEAKING). Frailty at baseline were assessed by FRAIL scale which included five items: fatigue, resistance, ambulation, illnesses, and loss of weight. Potential risk factors of frailty including age, sex, body mass index, and daily step counts recorded by ActiGraph GT3X + accelerometer were analyzed by multivariate logistic regression analysis.
Results
The prevalence of prefrailty and frailty was 50.0% and 11.9% in patients with stages 4–5 CKD, 29.6% and 9.3% in stage 3, and 32.1% and 0 in stages 1–2. In the multivariate logistic regression analysis, an increase of 100 steps per day (OR = 0.95, 95% CI 0.91–0.99, P = 0.01) and an increase of 5 units eGFR (OR = 0.82, 95% CI 0.68–0.99, P = 0.045) were inversely associated with being frail; higher BMI was associated with a higher likelihood of being frail (OR = 1.52, 95% CI 1.11–2.06, P = 0.008) and prefrail (OR = 1.25, 95% CI 1.10–1.42, P = 0.001).
Conclusion
Frailty and prefrailty were common in patients with advanced CKD. A lower number of steps per day, lower eGFR, and a higher BMI were associated with frailty in this population.
Funder
National Nature Science Foundation of China
Research Fund for Bajian Talents of Guangdong Provincial Hospital of Chinese Medicine
the Science and Technology Research Fund from Guangdong provincial hospital of Chinese medicine, China
the Karolinska Institutet’s internal funds
Traditional Chinese Medicine Bureau of Guangdong Province
The Spring Sunshine Program of Scientific Research Cooperation, Ministry of Education of China
National Administration of Traditional Chinese medicine, P.R. China
Karolinska Institute
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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