Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation

Author:

Mordi Ify R.ORCID,Santema Bernadet T.,Kloosterman Mariëlle,Choy Anna-Maria,Rienstra Michiel,van Gelder Isabelle,Anker Stefan D.,Cleland John G.,Dickstein Kenneth,Filippatos Gerasimos,van der Harst PimORCID,Hillege Hans L.,Metra Marco,Ng Leong L.,Ouwerkerk Wouter,Ponikowski Piotr,Samani Nilesh J.,van Veldhuisen Dirk J.,Zwinderman Aeilko H.,Zannad Faiez,Voors Adriaan A.,Lang Chim C.

Funder

FP7

Dutch Heart Foundation

Chief Scientist Office

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine,General Medicine

Reference33 articles.

1. Swedberg K, Komajda M, Bohm M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L (2010) Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet 376(9744):875–885. https://doi.org/10.1016/S0140-6736(10)61198-1

2. Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J (2009) The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. J Am Coll Cardiol 54(19):1747–1762. https://doi.org/10.1016/j.jacc.2009.05.015

3. Cullington D, Goode KM, Zhang J, Cleland JG, Clark AL (2014) Is heart rate important for patients with heart failure in atrial fibrillation? JACC Heart Fail 2(3):213–220. https://doi.org/10.1016/j.jchf.2014.01.005

4. Li SJ, Sartipy U, Lund LH, Dahlstrom U, Adiels M, Petzold M, Fu M (2015) Prognostic significance of resting heart rate and use of beta-blockers in atrial fibrillation and sinus rhythm in patients with heart failure and reduced ejection fraction: findings from the Swedish Heart Failure Registry. Circ Heart Fail 8(5):871–879. https://doi.org/10.1161/CIRCHEARTFAILURE.115.002285

5. Simpson J, Castagno D, Doughty RN, Poppe KK, Earle N, Squire I, Richards M, Andersson B, Ezekowitz JA, Komajda M, Petrie MC, McAlister FA, Gamble GD, Whalley GA, McMurray JJ (2015) Is heart rate a risk marker in patients with chronic heart failure and concomitant atrial fibrillation? Results from the MAGGIC meta-analysis. Eur J Heart Fail 17(11):1182–1191. https://doi.org/10.1002/ejhf.346

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