Abstract
Summary
Purpose
To evaluate gastrointestinal tract (GIT) perforations in very low birth weight infants and the effects on neurodevelopmental outcome.
Methods
Between 2000 and 2017 all cases with GIT perforation were analyzed regarding causes, associated morbidities and neurodevelopmental outcome and compared with matched (gestational age, birth weight, gender, year of birth) by 1:2 controls.
Results
The incidence of GIT perforation was 2.0% (n = 38/1878). Diagnoses associated with GIT were meconium obstruction of prematurity (MOP,n = 19/50%), spontaneous intestinal perforation (SIP, n = 7/18%), necrotizing enterocolitis (NEC, n = 6/16%), iatrogenic perforation (n = 3/8%), volvulus (n = 2/5%) and meconium ileus (n = 1/3%). The NEC-associated perforations occurred later compared to those associated with MOP and SIP (median 8 days and 6 days vs. 17 days, p = 0.001 and 0.023, respectively) and main localization was the terminal ileum (84%). Cases had higher rates of late onset sepsis (55% vs. 24%, p = 0.003), longer duration of mechanical ventilation (median 30 days vs 18 days, p = 0.013) and longer stays at the hospital (median 122 days vs 83 days, p < 0.001); mortality rates did not differ. The 2‑year neurodevelopment follow-up revealed no differences between groups (normal development 49% vs. 40%).
Conclusion
Despite increased morbidities preterm infants with GIT perforation did not have a higher mortality rate and groups did not differ regarding neurodevelopmental outcome at the corrected for prematurity age of 2 years.
Funder
Medical University of Graz
Publisher
Springer Science and Business Media LLC
Reference23 articles.
1. Sakellaris G, Partalis N, Dede O, et al. Gastrointestinal perforations in neonatal period: experience over 10 years. Pediatr Emerg Care. 2012;28:886–8.
2. Annigeri VM, Kulkarni V, Annigeri RV, Maralihalli M, Halgeri AB, Joshi SN. Gastrointestinal perforation in neonates. Karnataka Paediatr J. 2013;28:140–6.
3. Asabe K, Oka Y, Kai H, Shirakusa T. Neonatal gastrointestinal perforation. Turk J Pediatr. 2009;51:264–70.
4. Hakan N, Aydin M, Erdogan D, et al. Neonatal gastrointestinal perforations: a 7-year single center experience at a tertiary neonatal intensive care unit in Turkey. CIBTech J Surg. 2013;3:1–7.
5. Siddiqui MM, Drewett M, Burge DM. Meconium obstruction of prematurity. Arch Dis Child Fetal Neonatal Ed. 2012;97:F147–50.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献