Reply: assessing the effect of oral glutamine on the MELAS phenotype requires appropriate study designs
Author:
Funder
Fundación Eugenio Rodríguez Pascual
Fundación Mutua Madrileña
Publisher
Springer Science and Business Media LLC
Link
https://link.springer.com/content/pdf/10.1007/s00234-024-03299-x.pdf
Reference4 articles.
1. Guerrero-Molina MP, Bernabeu-Sanz Á, Ramos-González A, Morales-Conejo M, Delmiro A, Domínguez-González C, Arenas J, Martín MA, González de la Aleja J (2019) Magnetic resonance spectroscopy in MELAS syndrome: correlation with CSF and plasma metabolite levels and change after glutamine supplementation. Neuroradiology https://doi.org/10.1007/s00234-023-03263-1
2. Guerrero-Molina MP, Morales-Conejo M, Delmiro A, Morán M, Domínguez-González C, Arranz-Canales E, Ramos-González A, Arenas J, Martín MA, González de la Aleja J (2022) Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. J Neurol 269(6):3238–3248. https://doi.org/10.1007/s00415-021-10942-7
3. Guerrero-Molina MP, Morales-Conejo M, Delmiro A, Morán M, Domínguez-González C, Arranz-Canales E, Ramos-González A, Arenas J, Martín MA, de la Aleja JG (2022) High-dose oral glutamine supplementation reduces elevated glutamate levels in cerebrospinal fluid in patients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome. Eur J Neurol https://doi.org/10.1111/ene.15626
4. Moosa A, Hughes EA (1974) Proceedings: L-glutamine therapy in Leigh’s encephalomyelopathy. Arch Dis Child 49(3):246. https://doi.org/10.1136/adc.49.3.246
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