Promising Therapy for Heart Failure in Patients with Severe COVID-19: Calming the Cytokine Storm

Author:

Peng Xiang,Wang Yani,Xi Xiangwen,Jia Ying,Tian Jiangtian,Yu Bo,Tian JinweiORCID

Abstract

AbstractThe coronavirus disease 19 (COVID-19) pandemic poses a serious global threat to human health and the economy. Based on accumulating evidence, its continuous progression involves not only pulmonary injury but also damage to the cardiovascular system due to intertwined pathophysiological risks. As a point of convergence in the pathophysiologic process between COVID-19 and heart failure (HF), cytokine storm induces the progression of COVID-19 in patients presenting pre-existing or new onset myocardial damage and even HF. Cytokine storm, as a trigger of the progression of HF in patients with COVID-19, has become a novel focus to explore therapies for target populations. In this review, we briefly introduce the basis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and illuminate the mechanism and links among COVID-19, cytokine storm, and HF. Furthermore, we discuss drugs and therapeutic targets for patients with COVID-19 and HF.

Funder

National Natural Science Foundation of China

National Key R&D Program of China

Fok Ying-Tong Education Foundation for Young Teachers

Foundation of Guangxi Key Laboratory of Diabetic Systems Medicine

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cardiology and Cardiovascular Medicine,Pharmacology,General Medicine

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