Author:
Haack Thomas,González Ma. José,Sánchez Yolanda,Giralt Ernest
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Molecular Medicine,Biochemistry,Bioengineering,Analytical Chemistry,Biochemistry
Reference34 articles.
1. Among these exceptions, in prokaryotes, the use ofd-amino acids in bacterial cell-walls is well known. In eukaryotes, recently, several receptor agonists and neuroactive tetrapeptides containing ad-amino acid residue have been isolated from amphibian and mollusc. These peptides are synthesized via post-translational enzymatic epimerization from an all-l precursor: Heck, S.D., Faraci, W.S., Kelbaugh, P.R., Saccomano, N.A., Thadeio, P.F. and Volkmann, R.A., Proc. Natl. Acad. Sci. USA, 93 (1996) 4036; reviews: Lamzin, V.S., Dauter, Z. and Wilson, K.S., Curr. Opin. Struct. Biol., 5 (1995) 830; Mor, A., Amiche, M. and Nicolas, P., Trends Biochem. Sci., 17 (1992) 481. For other examples of racemases, but from prokaryotic origin, see References 3 and 4.
2. Mason, S.F., Nature, 311 (1984) 19.
3. Matthew, E., Zhi, J.Z. and Freundlich, M., J. Bacteriol., 178 (1996) 7234.
4. Yohda, M., Endo, I., Abe, Y., Ohta, T., Lida, T., Maruyama, T. and Kagawa, Y., J. Biol. Chem., 271 (1996) 22017.
5. All the genetically coded amino acids have only one stereogenic atom (the α-carbon atom), with the exception of isoleucine and threonine. In these two cases, the β-carbon is also stereogenic. The configuration of naturall-isoleucine is 2S, 3S and that ofl-threonine 2S, 3R. The configuration ofd-isoleucine is 2R, 3R and that ofd-threonine is 2R, 3S.
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