lncRNA H-19 and miR-200a implication and frequency of lncRNA H-19 rs2170425 SNP in ulcerative colitis and Crohn’s disease

Abstract

AbstractInflammation’s impact on inflammatory bowel diseases is mostly due to altered non-coding RNA expression. This study aimed to explore the rs2107425 polymorphism in the long non-coding RNA gene H19 (lncRNA H-19) and emphasize the involvement of miR-200a and lncRNA H-19 expression in ulcerative colitis (UC) and Crohn’s disease (CD). One hundred and ten participants, ranging in age from 22 to 58 years, participated in the current investigation study. Study participants were classified into forty healthy participants, thirty-four patients with UC, and thirty-six patients with CD. Participants with ulcerative colitis and Crohn’s disease experienced a considerable elevation in C-reactive protein, total leucocyte count (TLC), platelets, and erythrocyte sedimentation rate (ESR), whereas a noticeable decrease in hemoglobin. Additionally, ulcerative colitis and Crohn’s disease both have markedly increased expression of lncRNA H-19 and miR-200a. The frequency of the CT + TT genotype of the rs2170425 lncRNAH-19 SNP was linked to susceptibility to IBDs. lncRNA H-19 and miR-200a can be used as non-invasive diagnostic biomarkers for follow-up patients with ulcerative colitis and Crohn’s disease.