Knockdown of SDC-1 Gene Alleviates the Metabolic Pathway for the Development of MODS
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Published:2023-07-29
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Volume:
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ISSN:1073-6085
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Container-title:Molecular Biotechnology
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language:en
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Short-container-title:Mol Biotechnol
Author:
Xie Jiangang, Ma Yuexiang, Huang Yang, Wang Qianmei, Xu Yunyun, Zhang Qi, Yang Jing, Yin WenORCID
Abstract
AbstractThis study aims to reveal the metabolic differences between SDC-1 knockout mice and wild-type mice and the metabolic differences caused by shock in SDC-1 knockout mice by integrating transcriptomics and metabolomics. A total of 1009 differential metabolites were differentially expressed based on untargeted metabolomics and high-resolution mass spectrometry detection techniques. According to Kyoto Encyclopedia of Genes and Genomes enrichment, SDC-1 knockout significantly altered fat digestion and absorption, GnRH signaling pathway, fructose and mannose metabolism, and some other amino-related metabolic pathways and significantly modulated positively regulated longevity regulatory pathways, longevity regulatory pathways-worm, nicotinamide and niacinamide metabolism, and vitamin digestion and absorption pathways after its shock. Our findings indicate that SDC-1 knockout may have potential therapeutic effects in hemorrhagic shock by increasing nicotinamide metabolism.
Funder
Shanxi Provincial Key Research and Development Project Major Military Project
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Applied Microbiology and Biotechnology,Biochemistry,Bioengineering,Biotechnology
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