A Phase II combination trial with recombinant human tumor necrosis factor and gamma interferon in patients with colorectal cancer

Author:

Fiedler W.,Zeller W.,Peimann C. -J.,Weh H. -J.,Hossfeld D. K.

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Genetics (clinical),Drug Discovery,Molecular Medicine

Reference42 articles.

1. Abbruzzese JL, Levin B, Ajani JF, Faintuch JS, Saks S, Patt YZ, Edwards C, Ende K, Gutterman JU (1989) Phase I trial of recombinant human gamma-interferon and recombinant human tumor necrosis factor in patients with advanced gastrointestinal cancer. Cancer Res 49:4057–4061

2. Aggarwal BB, Eessalu TE, Hass PE (1985) Characterisation of receptors for human tumor necrosis factor and their regulation by g-interferon. Nature 318:665–667

3. Balkwill FR, Lee A, Aldam G, Moodie E, Thomas JA, Tavernier J, Fiers W (1986) Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons. Cancer Res 46:3990–3993

4. Beissert S, Bergholz M, Waase I, Lepsien G, Schauer A, Pfizenmaier K, Krönke M (1989) Regulation of tumor necrosis factor gene expression in colorectal adenocarcinoma: in vivo analysis by in situ hybridization. Proc Natl Acad Sci USA 86:5064–5068

5. Bertolini DR, Nedwin GE, Bringman TS, Smith DD, Mundy GR (1986) Stimulation of bone resorption and inhibition of bone formation in vitro by human tumor necrosis factors. Nature 319:516–518

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