Test–retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease
-
Published:2022-01-26
Issue:4
Volume:13
Page:583-594
-
ISSN:1868-4483
-
Container-title:Translational Stroke Research
-
language:en
-
Short-container-title:Transl. Stroke Res.
Author:
Binnie Lauren R., Pauls Mathilde M. H., Benjamin Philip, Dhillon Mohani-Preet K., Betteridge Shai, Clarke Brian, Ghatala Rita, Hainsworth Fearghal A. H., Howe Franklyn A., Khan Usman, Kruuse Christina, Madigan Jeremy B., Moynihan Barry, Patel Bhavini, Pereira Anthony C., Rostrup Egill, Shtaya Anan B. Y., Spilling Catherine A., Trippier Sarah, Williams Rebecca, Isaacs Jeremy D., Barrick Thomas R., Hainsworth Atticus H.ORCID
Abstract
AbstractCerebral small vessel disease (SVD) is common in older people and is associated with lacunar stroke, white matter hyperintensities (WMH) and vascular cognitive impairment. Cerebral blood flow (CBF) is reduced in SVD, particularly within white matter.Here we quantified test–retest reliability in CBF measurements using pseudo-continuous arterial spin labelling (pCASL) in older adults with clinical and radiological evidence of SVD (N=54, mean (SD): 66.9 (8.7) years, 15 females/39 males). We generated whole-brain CBF maps on two visits at least 7 days apart (mean (SD): 20 (19), range 7-117 days).Test–retest reliability for CBF was high in all tissue types, with intra-class correlation coefficient [95%CI]: 0.758 [0.616, 0.852] for whole brain, 0.842 [0.743, 0.905] for total grey matter, 0.771 [0.636, 0.861] for deep grey matter (caudate-putamen and thalamus), 0.872 [0.790, 0.923] for normal-appearing white matter (NAWM) and 0.780 [0.650, 0.866] for WMH (all p<0.001). ANCOVA models indicated significant decline in CBF in total grey matter, deep grey matter and NAWM with increasing age and diastolic blood pressure (all p<0.001). CBF was lower in males relative to females (p=0.013 for total grey matter, p=0.004 for NAWM).We conclude that pCASL has high test–retest reliability as a quantitative measure of CBF in older adults with SVD. These findings support the use of pCASL in routine clinical imaging and as a clinical trial endpoint.All data come from the PASTIS trial, prospectively registered at: https://eudract.ema.europa.eu (2015-001235-20, registered 13/05/2015), http://www.clinicaltrials.gov (NCT02450253, registered 21/05/2015).
Funder
alzheimer's drug discovery foundation uk alzheimer society national institute for health research
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine,Neurology (clinical),General Neuroscience
Reference53 articles.
1. Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O'Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, DeCarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge R, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van BM, Norrving B, Gorelick PB, Dichgans M. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013; 12:822-38. 2. Kynast J, Lampe L, Luck T, Frisch S, Arelin K, Hoffmann KT, Loeffler M, Riedel-Heller SG, Villringer A, Schroeter ML. White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory. J Cereb Blood Flow Metab. 2018;38:996–1009. 3. Esiri MM, Wilcock GK, Morris JH. Neuropathological assessment of the lesions of significance in vascular dementia. J Neurol Neurosurg Psychiatry. 1997;63:749–53. 4. Lawrence AJ, Patel B, Morris RG, Mackinnon AD, Rich PM, Barrick TR, Markus HS. Mechanisms of cognitive impairment in cerebral small vessel disease: multimodal MRI results from the St George's cognition and neuroimaging in stroke (SCANS) study. PLoS One. 2013; 8:e61014. 5. O’Brien JT, Thomas A. Vascular dementia. Lancet. 2015;386:1698–706.
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|