Engineering the methyltransferase through inactivation of the genK and genL leads to a significant increase of gentamicin C1a production in an industrial strain of Micromonospora echinospora 49-92S-Reference-Cited by-同舟云学术

Engineering the methyltransferase through inactivation of the genK and genL leads to a significant increase of gentamicin C1a production in an industrial strain of Micromonospora echinospora 49-92S

Published:2022-08-27 Issue:10 Volume:45 Page:1693-1703
ISSN:1615-7591
Container-title:Bioprocess and Biosystems Engineering
language:en
Short-container-title:Bioprocess Biosyst Eng

Author:

Xu Feng^ORCID,Zhang Xinyu,Liu Ling,Ke Xiang,Wu Jie,Guo Yuanxin,Tian Xiwei,Chu Ju

Funder

National Key Research and Development Program of China

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Bioengineering,Biotechnology

Link

https://link.springer.com/content/pdf/10.1007/s00449-022-02774-0.pdf

Reference27 articles.

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2. Li D, Li H, Ni X, Zhang H, Xia H (2013) Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. Microbiol Res 168(5):263–267. https://doi.org/10.1016/j.micres.2012.12.006

3. Rodriquez M, Cretoso DS, Euterpio MA, Russo P, Crescenzi C, Aquino RP (2015) Fast determination of underivatized gentamicin C components and impurities by LC-MS using a porous graphitic carbon stationary phase. Anal Bioanal Chem 407(25):7691–7701. https://doi.org/10.1007/s00216-015-8933-6

4. Yoshizawa S, Fourmy D, Puglisi JD (1998) Structural origins of gentamicin antibiotic action. EMBO J 17(22):6437–6448. https://doi.org/10.1093/emboj/17.22.6437

5. Bezdjian A, Mujica-Mota MA, Devic S, Daniel SJ (2015) The effect of radiotherapy on gentamicin ototoxicity: an animal model. Otolaryngol Head Neck Surg 152(6):1094–1101. https://doi.org/10.1177/0194599815573197

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