Controlling the feed rate of propanol to optimize erythromycin fermentation by on-line capacitance and oxygen uptake rate measurement

Author:

Guo Qian,Chu Ju,Zhuang Yingping,Gao Yang

Funder

Major State Basic Research Development Program of China

National Scientific and Technological Major Special Project

Research Fund for the Doctoral Program of Higher Education of China

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Bioengineering,Biotechnology

Reference31 articles.

1. Bao K, Zhang WG, Cheng MS (2009) Recent developments in erythromycin derivatives with new bioactivities. J Shenyang Pharm Univ 26(1):74–79

2. Mironov VA, Sergienko OV, Nastasyak IN, Danilenko VN (2004) Biogenesis and regulation of biosynthesis of erythromycins in Saccharopolysplra erythraea. Appl Biochem Microbiol 6:611–624

3. Sun Y, Zhou RQ, Wu Q (2005) Biochemistry and genetics of erythromycin biosynthesis. J Microbiol 25(2):45

4. Andrew R, Reeves Igor A, Brikun William H (2006) Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea. J Ind Microbiol Biotechnol 33(7):600–609

5. Chen Y, Deng W, Wu JQ (2008) Genetic modulation of the over expression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythrae. Appl Environ Microbiol Ferment 74(6):1820–1828

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