Selective blockade of IL-21 by myricetin impedes T follicular helper cell differentiation by negatively regulating the JAK/STAT/Bcl-6 pathway in a rheumatoid arthritis animal model
Author:
Publisher
Springer Science and Business Media LLC
Subject
Agricultural and Biological Sciences (miscellaneous),Environmental Science (miscellaneous),Biotechnology
Link
https://link.springer.com/content/pdf/10.1007/s13205-023-03880-w.pdf
Reference21 articles.
1. Bryant VL, Ma CS, Avery DT et al (2007) Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol 179:8180–8190
2. Chillingworth NL, Donaldson LF (2003) Characterisation of a Freund’s complete adjuvant-induced model of chronic arthritis in mice. J Neurosci Methods 128(1–2):45–52. https://doi.org/10.1016/s0165-0270(03)00147-x
3. Derksen V, Huizinga T, van der Woude D (2019) The role of autoantibodies in the pathophysiology of rheumatoid arthritis. Semin Immunopathol 39(4):437–446. https://doi.org/10.1007/s00281-017-0627-z
4. George G, Shyni GL, Raghu KG (2020) Current and novel therapeutic targets in the treatment of rheumatoid arthritis. Inflammopharmacol 28(6):1457–1476. https://doi.org/10.1007/s10787-020-00757-9
5. Hao Y, Xie L, Xia J, Liu Z, Yang B, Zhang M (2021) Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis. BMC Musculoskelet Disord 22(1):246. https://doi.org/10.1186/s12891-021-04111-0
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