Author:
Chen Xueyi,Zhang Yangdong,Wang Haiyang,Liu Lanxiang,Li Wenwen,Xie Peng
Abstract
AbstractLactic acid is produced mainly in astrocytes in the brain and serves as a substance that supplies energy to neurons. In recent years, numerous studies identified the potential effects of lactic acid on the central nervous system and demonstrated its role in regulating brain function as an energy metabolism substrate or cellular signaling molecule. Both deficiency and accumulation of lactic acid cause neurological dysfunction, which further lead to the development of neuropsychiatric disorders, such as Major depressive disorder, Schizophrenia, Alzheimer’s disease, and Multiple sclerosis. Although an association between lactic acid and neuropsychiatric disorders was reported in previous research, the underlying pathogenic mechanisms remain unclear. Therefore, an in-depth understanding of the molecular mechanisms by which lactic acid regulates brain function is of significance for the early diagnosis and prevention of neuropsychiatric disorders. In this review, we summarize evidence that is focused on the potential mechanisms of lactic acid as a signaling molecule involved in the pathogenesis of neuropsychiatric disorders and propose a new mechanism by which lactic acid regulates brain function and disease through the microbiota–gut–brain axis to offer new insight into the prevention and treatment of neuropsychiatric diseases.
Funder
China Postdoctoral Science Foundation
National Key Research and Development Program of China
Central Research Institute Fund of the Chinese Academy of Medical Sciences
Natural Science Foundation Project of China
Publisher
Springer Science and Business Media LLC
Cited by
10 articles.
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