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Transcriptomic Characterization of a Human In Vitro Model of Arrhythmogenic Cardiomyopathy Under Topological and Mechanical Stimuli

  • Published:2018-12-19 Issue:3 Volume:47 Page:852-865
  • ISSN:0090-6964
  • Container-title:Annals of Biomedical Engineering
  • language:en
  • Short-container-title:Ann Biomed Eng

Author:

Martewicz Sebastian,Luni Camilla,Serena Elena,Pavan Piero,Chen Huei-Sheng Vincent,Rampazzo Alessandra,Elvassore NicolaORCID

Funder

ShanghaiTech University

Oak Foundation

Università degli Studi di Padova

Regione del Veneto

National Institutes of Health

Krannert Institute of Cardiology

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering

Reference53 articles.

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2. Asimaki, A., and J. E. Saffitz. Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy. Cell Commun. Adhes. 21:13–23, 2014.

3. Bezzina, C. R., J. Barc, Y. Mizusawa, C. A. Remme, J.-B. Gourraud, F. Simonet, A. O. Verkerk, P. J. Schwartz, L. Crotti, F. Dagradi, P. Guicheney, V. Fressart, A. Leenhardt, C. Antzelevitch, S. Bartkowiak, E. Schulze-Bahr, S. Zumhagen, E. R. Behr, R. Bastiaenen, J. Tfelt-Hansen, M. S. Olesen, S. Kääb, B. M. Beckmann, P. Weeke, H. Watanabe, N. Endo, T. Minamino, M. Horie, S. Ohno, K. Hasegawa, N. Makita, A. Nogami, W. Shimizu, T. Aiba, P. Froguel, B. Balkau, O. Lantieri, M. Torchio, C. Wiese, D. Weber, R. Wolswinkel, R. Coronel, B. J. Boukens, S. Bézieau, E. Charpentier, S. Chatel, A. Despres, F. Gros, F. Kyndt, S. Lecointe, P. Lindenbaum, V. Portero, J. Violleau, M. Gessler, H. L. Tan, D. M. Roden, V. M. Christoffels, H. Le Marec, A. A. Wilde, V. Probst, J.-J. Schott, C. Dina, and R. Redon. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat. Genet. 45:1044–1049, 2013.

4. Bray, M. A., S. P. Sheehy, and K. K. Parker. Sarcomere alignment is regulated by myocyte shape. Cell Motil. Cytoskelet. 65:641–651, 2008.

5. Brodehl, A., D. D. Belke, L. Garnett, K. Martens, N. Abdelfatah, M. Rodriguez, C. Diao, Y. X. Chen, P. M. Gordon, A. Nygren, and B. Gerull. Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling. PLoS ONE 12:e0174019, 2017.

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