Impact of Tryptophan Oxidation in Complementarity-Determining Regions of Two Monoclonal Antibodies on Structure-Function Characterized by Hydrogen-Deuterium Exchange Mass Spectrometry and Surface Plasmon Resonance

Author:

Hageman Tyler,Wei HuiORCID,Kuehne Patrick,Fu Jinmei,Ludwig Richard,Tao Li,Leone Anthony,Zocher Marcel,Das Tapan K.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology

Reference42 articles.

1. Cai HH. Therapeutic monoclonal antibodies approved by FDA in 2016. MOJ Immunol. 2017;5(1):00145.

2. Reichert JM. Antibodies to watch in 2017. MAbs. 2017;9(2):167–81.

3. Kaplon H, Reichert JM. Antibodies to watch in 2018. MAbs. 2018;10(2):183–203.

4. Ducancel F, Muller BH. Molecular engineering of antibodies for therapeutic and diagnostic purposes. MAbs. 2012;4(4):445–57.

5. Strohl WR, Strohl LM. Therapeutic antibody engineering: current and future advances driving the strongest growth area in the pharmaceutical industry: WP/Woodhead publishing; 2012.

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