Mechanistic Modeling of the Effect of Recombinant Human Hyaluronidase (rHuPH20) on Subcutaneous Delivery of Cetuximab in Rats
Author:
Funder
Halozyme Therapeutics
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology
Link
https://link.springer.com/content/pdf/10.1007/s11095-022-03294-y.pdf
Reference38 articles.
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3. Bittner B, Richter WF, Hourcade-Potelleret F, Herting F, Schmidt J. Non-clinical pharmacokinetic/pharmacodynamic and early clinical studies supporting development of a novel subcutaneous formulation for the monoclonal antibody rituximab. Drug Res (Stuttg). 2014;64(11):569–75.
4. Jackisch C, Muller V, Maintz C, Hell S, Ataseven B. Subcutaneous Administration of Monoclonal Antibodies in oncology. Geburtshilfe Frauenheilkd. 2014;74(4):343–9.
5. Bookbinder LH, Hofer A, Haller MF, Zepeda ML, Keller GA, Lim JE, Edgington TS, Shepard HM, Patton JS, Frost GI. A recombinant human enzyme for enhanced interstitial transport of therapeutics. J Control Release. 2006;114(2):230–41.
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