Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19

Author:

Baker Nancy,Williams Antony J.,Tropsha Alexander,Ekins SeanORCID

Funder

National Institute of General Medical Sciences

National Center for Advancing Translational Sciences

National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology

Reference24 articles.

1. Gates B. Responding to Covid-19 - a once-in-a-century pandemic? N Engl J Med. 2020;382:1677–9.

2. Ekins S, Mottin M, Ramos PRPS, Sousa BKP, Neves BJ, Foil DH, Zorn KM, Braga RC, Coffee M, Southan C, Puhl AC, Andrade CH. Déjà vu: Stimulating Open Drug Discovery for SARS-CoV-2. Drug Discov Today. 2020; Apr 19:S1359-6446(20)30145-8. https://doi.org/10.1016/j.drudis.2020.03.019.

3. Stebbing J, Phelan A, Griffin I, Tucker C, Oechsle O, Smith D, et al. COVID-19: combining antiviral and anti-inflammatory treatments. Lancet Infect Dis. 2020;20(4):400–2.

4. Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs. Available from: https://www.biorxiv.org/content/10.1101/2020.03.20.999730v1.

5. Jin Z, Du X, Xu Y, Deng Y, Liu M, Zhao Y, Zhang B, Li X, Zhang L, Peng C, Duan Y, Yu J, Wang L, Yang K, liu F, Jiang R, Yang X, You T, Liu X, Yang X, Bai F, Liu H, Liu X, Guddat LW, Xu W, Xiao G, Qin C, Shi Z, Jiang HY, Rao Z, yang H. Structure of Mpro from 1 COVID-19 virus and discovery of its inhibitors. Available from: https://www.biorxiv.org/content/10.1101/2020.02.26.964882v2.

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