A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2-Positive Brain Metastatic Localizations
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology
Link
https://link.springer.com/content/pdf/10.1007/s11095-023-03614-w.pdf
Reference45 articles.
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2. Lazaratos AM, Maritan SM, Quaiattini A, Darlix A, Ratosa I, Ferraro E, et al. Intrathecal trastuzumab versus alternate routes of delivery for HER2-targeted therapies in patients with HER2+ breast cancer leptomeningeal metastases. Breast. 2023;0. Available from: http://www.thebreastonline.com/article/S0960977623004502/fulltext.
3. Tan YO, Han S, Lu YS, Yip CH, Sunpaweravong P, Jeong J, et al. The prevalence and assessment of ErbB2-positive breast cancer in Asia. Cancer. 2010;116:5348–57. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/cncr.25476.
4. Thomas KH, Ramirez RA. Leptomeningeal disease and the evolving role of molecular targeted therapy and immunotherapy. Ochsner J. 2017;17:362.
5. Stemmler H-J, Schmitt M, Willems A, Bernhard H, Harbeck N, Heinemann V. Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier. Anticancer Drugs. 2007;18:23–8. Available from: https://insights.ovid.com/crossref?an=00001813-200701000-00004.
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