Comparison of Relative Activity versus Relative Expression Factors (RAF versus REF) in Predicting Glucuronidation Mediated Drug Clearance Using Recombinant UGTs-Reference-Cited by-同舟云学术

Comparison of Relative Activity versus Relative Expression Factors (RAF versus REF) in Predicting Glucuronidation Mediated Drug Clearance Using Recombinant UGTs

Published:2024-08 Issue:8 Volume:41 Page:1621-1630
ISSN:0724-8741
Container-title:Pharmaceutical Research
language:en
Short-container-title:Pharm Res

Author:

Subash Sandhya,Ahire Deepak,Patel Mitesh,Shaikh Sahil,Singh Dilip Kumar,Deshmukh Sujal,Prasad Bhagwat

Funder

Novartis Institutes for BioMedical Research

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1007/s11095-024-03750-x.pdf

Reference41 articles.

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4. Huang M, Lou C, Wu Z, Li W, Lee PW, Tang Y, Liu G. In silico prediction of UGT-mediated metabolism in drug-like molecules via graph neural network. J Cheminform. 2022. https://doi.org/10.1186/s13321-022-00626-3.

5. Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, Peterkin V, Koup JR, Ball SE. Drug-drug interactions for UDP-glucuronosyltransferase substrates: A pharmacokinetic explanation for typically observed low exposure (AUC 1/AUC) ratios. Drug Metab Dispos. 2004;32:1201–8.