Effects of Histidine and Sucrose on the Biophysical Properties of a Monoclonal Antibody
Author:
Funder
Bristol-Myers Squibb
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology
Link
http://link.springer.com/content/pdf/10.1007/s11095-016-2092-0.pdf
Reference34 articles.
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3. Jiskoot W, Randolph TW, Volkin DB, Middaugh CR, Schöneich C, Winter G, et al. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. J Pharm Sci. 2012;101(3):946–54.
4. Salinas BA, Sathish HA, Bishop SM, Harn N, Carpenter JF, Randolph TW. Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation. J Pharm Sci. 2010;99(1):82–93.
5. Binabaji E, Ma J, Zydney AL. Intermolecular interactions and the viscosity of highly concentrated monoclonal antibody solutions. Pharm Res. 2015;32(9):3102–9.
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