Intestinal Lymphatic Transport Enhances the Post-Prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-Pass Metabolism-Reference-Cited by-同舟云学术

Intestinal Lymphatic Transport Enhances the Post-Prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-Pass Metabolism

Published:2009-03-12 Issue:6 Volume:26 Page:1486-1495
ISSN:0724-8741
Container-title:Pharmaceutical Research
language:en
Short-container-title:Pharm Res

Author:

Trevaskis Natalie L.,Shackleford David M.,Charman William N.,Edwards Glenn A.,Gardin Anne,Appel-Dingemanse Silke,Kretz Olivier,Galli Bruno,Porter Christopher J. H.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology

Link

http://link.springer.com/content/pdf/10.1007/s11095-009-9860-z.pdf

Reference26 articles.

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2. C. M. O’Driscoll. Lipid-based formulations for intestinal lymphatic delivery. Eur. J. Pharm. Sci. 15:405–415 (2002). doi: 10.1016/S0928-0987(02)00051-9 .

3. D. M. Karpf, R. Holm, H. G. Kristensen, and A. Mullertz. Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats. Pharm. Res. 21:1413–1418 (2004). doi: 10.1023/B:PHAM.0000036915.03725.19 .

4. A. Dahan, R. Duvdevani, I. Shapiro, A. Elmann, E. Finkelstein, and A. Hoffman. The oral absorption of phospholipid prodrugs: in vivo and in vitro mechanistic investigation of trafficking of a lecithin-valproic acid conjugate following oral administration. J. Control Release. 126:1–9 (2008). doi: 10.1016/j.jconrel.2007.10.025 .

5. A. Dahan, A. Mendelman, S. Amsili, N. Ezov, and A. Hoffman. The effect of general anesthesia on the intestinal lymphatic transport of lipophilic drugs: comparison between anesthetized and freely moving conscious rat models. Eur. J. Pharm. Sci. 32:367–374 (2007).

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