Testing Precision Limits of Neural Network-Based Quality Control Metrics in High-Throughput Digital Microscopy

Author:

Calderon Christopher P.ORCID,Ripple Dean C.,Srinivasan Charudharshini,Ma Youlong,Carrier Michael J.,Randolph Theodore W.,O’Connor Thomas F.

Funder

National Institutes of Health

U.S. Food and Drug Administration

SentrySciences LLC

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology

Reference34 articles.

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2. Calderon, C.P., Daniels, A.L., Randolph, T.W.: Deep Convolutional Neural Network Analysis of Flow Imaging Microscopy Data to Classify Subvisible Particles in Protein Formulations. Journal of Pharmaceutical Sciences 107(4), 999–1008 (2018). https://doi.org/10.1016/j.xphs.2017.12.008.http://linkinghub.elsevier.com/retrieve/pii/S002235491730878X.

3. Cavicchi, R.E., Ripple, D.C.: Improving Diameter Accuracy for Dynamic Imaging Microscopy for Different Particle Types. Journal of Pharmaceutical Sciences 109(1), 488–495 (2020). https://doi.org/10.1016/j.xphs.2019.10.017.https://doi.org/10.1016/j.xphs.2019.10.017.

4. D’Amour, A., Heller, K., Moldovan, D., Adlam, B., Alipanahi, B., Beutel, A., Chen, C., Deaton, J., Eisenstein, J., Hoffman, M.D., Hormozdiari, F., Houlsby, N., Hou, S., Jerfel, G., Karthikesalingam, A., Lucic, M., Ma, Y., McLean, C., Mincu, D., Mitani, A., Montanari, A., Nado, Z., Natarajan, V., Nielson, C., Osborne, T.F., Raman, R., Ramasamy, K., Sayres, R., Schrouff, J., Seneviratne, M., Sequeira, S., Suresh, H., Veitch, V., Vladymyrov, M., Wang, X., Webster, K., Yadlowsky, S., Yun, T., Zhai, X., Sculley, D.: Underspecification presents challenges for credibility in modern machine learning (2020)

5. Daniels, A.L., Calderon, C.P., Randolph, T.W.: Machine learning and statistical analyses for extracting and fingerprints of antibody aggregation at container interfaces from flow microscopy images. Biotechnology and Bioengineering 117(11), 3322–3335 (2020). https://doi.org/10.1002/bit.27501.https://onlinelibrary.wiley.com/doi/abs/10.1002/bit.27501.

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