Population Pharmacokinetic Analysis of Simvastatin and its Active Metabolite with the Characterization of Atypical Complex Absorption Kinetics-Reference-Cited by-同舟云学术

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Population Pharmacokinetic Analysis of Simvastatin and its Active Metabolite with the Characterization of Atypical Complex Absorption Kinetics

Published:2014-02-19 Issue:7 Volume:31 Page:1801-1812
ISSN:0724-8741
Container-title:Pharmaceutical Research
language:en
Short-container-title:Pharm Res

Author:

Jin Seok-Joon,Bae Kyun-Seop,Cho Sang-Heon,Jung Jin-Ah,Kim Unjib,Choe Sangmin,Ghim Jong-Lyul,Noh Yook-Hwan,Park Hyun-Jung,Kim Hee-sun,Lim Hyeong-Seok

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology

Link

http://link.springer.com/content/pdf/10.1007/s11095-013-1284-0.pdf

Reference25 articles.

1. Alberts AW, Chen J, Kuron G, Hunt V, Huff J, Hoffman C, et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A. 1980;77:3957–61.

2. Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu Y, Lin JH, et al. Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos. 2002;30:505–12.

3. Prueksaritanont T, Qiu Y, Mu L, Michel K, Brunner J, Richards KM, et al. Interconversion pharmacokinetics of simvastatin and its hydroxy acid in dogs: effects of gemfibrozil. Pharm Res. 2005;22:1101–9.

4. Merck Sharpe & Dohme. Manufacturer Information, Zocor: simvastatin. PA: West Point; 1991.

5. Kim J, Ahn BJ, Chae HS, Han S, Doh K, Choi J, et al. A Population Pharmacokinetic-PharmacodynamicModel for Simvastatin that Predicts Low-Density Lipoprotein-Cholesterol Reduction in Patients with Primary Hyperlipidaemia. Basic Clin Pharmacol Toxicol. 2011;109:156–63.

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