Heat capacities of active pharmaceutical ingredients nifedipine, griseofulvin, probucol and 5,5-diphenylhydantoin

Abstract

AbstractThe isobaric condensed-phase heat capacities of selected pharmaceutical active ingredients (APIs), namely nifedipine (CAS RN: 21829-25-4), griseofulvin (CAS RN: 126-07-8), probucol (CAS RN: 23288-49-5) and 5,5-diphenylhydantoin (CAS RN: 57-41-0), were determined over a wide temperature range starting from 2 K by combination of relaxation (heat pulse) calorimetry, Tian-Calvet calorimetry and power-compensated differential scanning calorimetry. Heat capacity measurements were taken for clearly specified polymorphs, a liquid phase (including subcooled liquid) and a glassy amorphous phase, if feasible. For 5,5-diphenylhydantoin, a heat capacity anomaly was detected in the temperature range 160 to 190 K and interpreted based on additional calorimetric and temperature-variable crystallographic measurements as a sequence of two phase transitions, which are reported for the first time in this work. Based on the determined phase behavior and heat capacity data from near 0 K, standard thermodynamic functions for crystalline and liquid phases were calculated for all APIs studied. This work significantly extends the availability of reliable heat capacity data and related thermodynamic properties for APIs required for modeling their solubility and other applications involving thermodynamic modeling.