Abstract
AbstractThis study presents a novel type of biopolymer patches in which anti-inflammatory drugs and amide-type anesthetics were simultaneously incorporated. Since the biopolymer matrix is composed of k-carrageenan, hydroxyethyl cellulose, and glycerol, as a plasticizer, the resulting patches have an elasticity and a “stickiness” that can be exploited in the field of transdermal delivery of drugs. Combinations of anesthetic and anti-inflammatory drugs resulted in twenty patches with a unique and distinct physical appearance. Furthermore, as indicated by FTIR, TG/DTG, and DSC analysis data, none of the active substances affects the integrity of the biopolymer matrix; instead, they influence the Tmelting of the patch matrix, either in its value increase or decrease.
Publisher
Springer Science and Business Media LLC
Reference38 articles.
1. Wen H, Jung H, Li X. Drug delivery approaches in addressing clinical pharmacology-related issues: opportunities and challenges. AAPS Journal. 2015;17(6):1327–40. https://doi.org/10.1208/s12248-015-9814-9.
2. Tewabe A, Abate A, Tamrie M, Seyfu A, and Siraj EA, Targeted drug delivery—from magic bullet to nanomedicine: Principles, challenges, and future perspectives. J Multidiscip Healthcare 2021;14:1711–1724. Dove Medical Press Ltd. https://doi.org/10.2147/JMDH.S313968.
3. . Elsewedy HS, AlDhubiab BE, Mahdy MA, Elnahas HM, A review article on the basic concepts of drug delivery systems as targeting agents. Int J Pharma Med Biol Sci, 2021;10(1):23–29. https://doi.org/10.18178/ijpmbs.10.1.23-29.
4. Li C et al., Recent progress in drug delivery. Acta Pharm Sin B. Chinese Academy of Medical Sciences, 2019;9(6):1145–1162. https://doi.org/10.1016/j.apsb.2019.08.003.
5. Taksande JB, Gupta M, Trivedi RV, Wadher J, Umekar MJ, Formulation and characterization of organic-inorganic hybrid film for transdermal drug delivery. J Appl Pharmaceut Res., 4(3):08–15. [Online]. Available: https://media.neliti.com/media/publications/320066-formulation-and-characterization-of-orga-9c88b690.pdf