Personalization matters: the effect of sex in multivitamin-multimineral-based cancer prevention
-
Published:2023-08-10
Issue:1
Volume:46
Page:1351-1356
-
ISSN:2509-2723
-
Container-title:GeroScience
-
language:en
-
Short-container-title:GeroScience
Author:
Šelb JulijORCID, Cvetko Filip, Deutsch LeonORCID, Bedrač Leon, Kuščer Enej, Maier Andrea BrittaORCID
Abstract
AbstractThe prevention of non-communicable diseases like cancer contributes to healthy aging. Dietary supplements might support such prevention; their effect likely depends on the personal characteristics of the individuals receiving them. To evaluate the influence of sex on reducing cancer incidence with multivitamin-multimineral (MVM) supplementation, sex-specific results of the efficacy of MVM supplementation for cancer prevention were collected and meta-analyzed (using fixed effect (FE) and random effect (RE) models). Three trials included in the “US Preventive Services Task Force Recommendation Statement Report regarding Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer” were used, namely, COSMOS, SU.VI.MAX, and PHS2. A total of 28,558 men and 20,542 women were included. Multivitamin-multimineral supplementation significantly reduced cancer incidence in the entire population (HR 0.93 [95% CI, 0.88–0.99], FE and RE); sex-specific meta-analysis showed beneficial effects of supplementation in men (HR 0.91 [95% CI, 0.85–0.97] (FE)/0.88 [95% CI, 0.77–1.01] (RE)); however, there was no effect in women (HR 1.00 [95% CI, 0.88–1.14], FR and RE); (Pdifference = 0.17). Sex could influence the effect of MVM supplementation in reducing cancer incidence, with supplementation being effective only in male individuals. These results might be informative for future research and public health policy makers.
Publisher
Springer Science and Business Media LLC
Subject
Geriatrics and Gerontology,Aging
Reference19 articles.
1. Keum N, Chen QY, Lee DH, Manson JE, Giovannucci E. Vitamin D supplementation and total cancer incidence and mortality by daily vs. infrequent large-bolus dosing strategies: a meta-analysis of randomised controlled trials. Br J Cancer. 2022. https://doi.org/10.1038/s41416-022-01850-2 2. Barry EL, Lund JL, Westreich D, Mott LA, Ahnen DJ, Beck GJ, Bostick RM, Bresalier RS, Burke CA, Church TR, Rees JR, Robertson DJ, Baron JA. Body mass index, calcium supplementation and risk of colorectal adenomas. Int J Cancer. 2019. https://doi.org/10.1002/ijc.31803. 3. Seufferlein T, Ettrich TJ, Menzler S, Messmann H, Kleber G, Zipprich A, Frank-Gleich S, Algül H, Metter K, Odemar F, Heuer T, Hügle U, Behrens R, Berger AW, Scholl C, Schneider KL, Perkhofer L, Rohlmann F, Muche R, Stingl JC. Green tea extract to prevent colorectal adenomas, results of a randomized, placebo-controlled clinical trial. Am J Gastroenterol. 2022. https://doi.org/10.14309/ajg.0000000000001706 4. Hall KT, Buring JE, Mukamal KJ, Vinayaga Moorthy M, Wayne PM, Kaptchuk TJ, Battinelli EM, Ridker PM, Sesso HD, Weinstein SJ, Albanes D, Cook NR, Chasman DI. COMT and alpha-tocopherol effects in cancer prevention: gene-supplement interactions in two randomized clinical trials. J Natl Cancer Inst. 2019. https://doi.org/10.1093/jnci/djy204. 5. Sesso HD, Rist PM, Aragaki AK, Rautiainen S, Johnson LG, Friedenberg G, Copeland T, Clar A, Mora S, Moorthy MV, Sarkissian A, Wactawski-Wende J, Tinker LF, Carrick WR, Anderson GL, Manson JE, Manson JE, Sesso HD, Rist PM, Lagerstrom SR, Bassuk SS, Wang L, Hazra A, Gibson H, Leboff MS, Mora S, Okereke OI, Tobias DK, Cook NR, Chandler PD, Christen W, Friedenberg G, Copeland T, Hanna J, Clar A, D’Agostino D, Vinayagamoorthy M, Gibson H, Kim E, Van Denburgh M, Kotler G, Li C, Bubes V, Sarkissian A, Smith D, Pereira EC, Okeke M, Roche E, Bates D, Ridge C, Phillips A, Salvo B, Wilson A, Hall L, Baez J, Sim YH, Cardoso H, Senor G, Rudnicki C, Huynh H, Nguyen V, Terrell N, Holman BA, Walter J, Johnson LF, Casarella A, O’Connell J, Christen W, Lagerstrom SR, Djoussé L, Chandler PD, Hazra A, Tobias DK, Farukhi ZM, Wang L, Zhang X, Breen K, Menjin GV, Rodriguez R, Curry S, Mora S, Arsenault L, Solano O, Weinberg A, Coates J, Kilroe M, Zernicke L, Hasson K, Matthew K, Mora S, Pfeffer C, Duszlak J, Bates D, Guzman V, Falcon J, Romero A, Kupets H, Cortez F, Lesuer JC, Hrbek A, Bowes E, Quinn P, Mele M, Anderson GL, Johnson L, Tinker LF, Aragaki AK, Herndon M, Mann SL, Pettinger M, Hunt RP, Carrick B, Szyperski K, Proulx-Burns L, Burrows E, Limacher M, Hsia J, Asaithambi G, Khan M, Nagaraja N, Ocava LC, Wold J, Silver B, Connelly S, Van Lom G, Garvida C, Hightower K, Spaulding P, Lin W, Schoenberg J, Olee P, Cohen LS, Colton T, Henderson IC, Hulley S, Lichtenstein AH, Passamani ER, Silliman RA, Wenger N, Ludlam SE, Schroeter H, Fare M, Ottawani J, Kwik-Uribe C, Arnaiz C, Costanza A, Greene J, Hennessey P, Vadlamani S, Karmsetty M, Martini P, Van Klinken JW, Shah A, Stern L. Multivitamins in the prevention of cancer and cardiovascular disease: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial. Am J Clin Nutr. 2022. https://doi.org/10.1093/ajcn/nqac056.
|
|