Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence
Author:
Funder
National Institute on Aging
National Cancer Institute
Publisher
Springer Science and Business Media LLC
Subject
Geriatrics and Gerontology,Aging
Link
https://link.springer.com/content/pdf/10.1007/s11357-022-00709-x.pdf
Reference36 articles.
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3. Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, et al. Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan. Nature. 2016;530:184–9. https://doi.org/10.1038/nature16932.
4. Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, et al. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018;24:1246–56. https://doi.org/10.1038/s41591-018-0092-9.
5. Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, van Deursen JM. Senescent cells: an emerging target for diseases of ageing. Nat Rev Drug Discov. 2017;16:718–35. https://doi.org/10.1038/nrd.2017.116.
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