A ride through the epigenetic landscape: aging reversal by reprogramming-Reference-Cited by-同舟云学术

A ride through the epigenetic landscape: aging reversal by reprogramming

Published:2021-04 Issue:2 Volume:43 Page:463-485
ISSN:2509-2715
Container-title:GeroScience
language:en
Short-container-title:GeroScience

Author:

de Lima Camillo Lucas Paulo^ORCID,Quinlan Robert B. A.

Abstract

AbstractAging has become one of the fastest-growing research topics in biology. However, exactly how the aging process occurs remains unknown. Epigenetics plays a significant role, and several epigenetic interventions can modulate lifespan. This review will explore the interplay between epigenetics and aging, and how epigenetic reprogramming can be harnessed for age reversal. In vivo partial reprogramming holds great promise as a possible therapy, but several limitations remain. Rejuvenation by reprogramming is a young but rapidly expanding subfield in the biology of aging.

Publisher

Springer Science and Business Media LLC

Subject

Geriatrics and Gerontology,Aging

Link

https://link.springer.com/content/pdf/10.1007/s11357-021-00358-6.pdf

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