Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution

Author:

Contreras Nico A.,Fontana Luigi,Tosti Valeria,Nikolich-Žugich Janko

Funder

National Institute on Aging

Bakewell Foundation

Longer Life Foundation

National Center for Research Resources

Publisher

Springer Science and Business Media LLC

Subject

Geriatrics and Gerontology,Ageing

Reference43 articles.

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2. Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D (2016) Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature 532:512–516. https://doi.org/10.1038/nature17655

3. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD (2015) A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan. Cell Metab 22:86–99. https://doi.org/10.1016/j.cmet.2015.05.012

4. Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD (2014) Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell 14:810–823. https://doi.org/10.1016/j.stem.2014.04.014

5. Čičin-Šain L, Messaoudi I, Park B, Currier N, Planer S, Fischer M, Tackitt S, Nikolich-Zugich D, Legasse A, Axthelm MK, Picker LJ, Mori M, Nikolich-Žugich J (2007) Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates. Proc Natl Acad Sci 104:19960–19965. https://doi.org/10.1073/pnas.0705905104

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